Powerful Cell Hack: Mitochondria Supplements for Improved Energy

Author : Ari Whitten
Medical Reviewer: Evan Hirsch, M.D.

Mitochondria Powerful_Cell_Hack

Background on Mitochondria

Eating a healthy, phytonutrient-rich diet, exercising regularly, and getting good quality sleep are vitally important for improving energy levels, it is often difficult to do while balancing the demands of life. This is where supplements can play an essential role in mitochondrial health.

We don’t believe you should rely on supplements to increase energy or fix health issues, but we do think they can play a role in complementing a healthy lifestyle.

A study published in the Journal of the International Society of Sports Nutrition showed that it’s tough to get all the essential vitamins and minerals you need from food alone. This study analyzed the diets of 70 athletes, and every single one was deficient in at least three nutrients. Some diets were missing up to fifteen nutrients! 1 The most common vitamins and minerals lacking in the modern diet are B vitamins, calcium, potassium, iron, zinc, magnesium, and selenium.

Before supplementing, it is vital to find out the cause of your fatigue. Blood tests can help you determine if you have any vitamin or mineral deficiencies. Work with your health care provider to assess your results, decide on a treatment plan for your fatigue, and determine the safety and efficacy of supplements you use.

There are many supplements out there that have a lot of hype and anecdotal feedback but lack scientific evidence, so beware! We will only be focusing here on compounds that have good, trustworthy, science-backed studies for supporting energy levels that are directly linked to cellular energy.

Dietary Supplements Commonly Used for Therapy: Mitochondrial Membrane Support

NT-Factor Phospholipid Complex

One of the most powerful compounds for mitochondrial regeneration. NT-Factors is a compound used in lipid replacement therapy, a method of replacing damaged membrane glycerophospholipids that accumulate during aging and in various clinical conditions in order to restore cellular and mitochondrial function. It has been shown to reduce fatigue by a whopping 24–43% in people with chronic fatigue syndrome 2 3 4 5, as well as reduce cancer-associated fatigue in just a few weeks of use. 6 7


A  red pigment found in krill and other seafood. Due to its special ability to penetrate inside of cells and incorporate itself inside its mitochondrial membranes, Astaxanthin is known to protect the mitochondria against oxygen radicals, conserve their antioxidant capacity and enhance their energy production efficiency. It is thought to be one of the most effective antioxidants known to man. It can increase blood flow 8, reduce the oxidation of LDL 9, and improve cognitive function. 10

Astaxanthin also modulates blood glucose 11 increasing levels of Orexin and, hence, energy levels. One study showed that Astaxanthin might even have anti-aging properties. 12

As astaxanthin is fat-soluble, it is best taken with a meal containing fats and should be taken either a few hours before or after exercise.

Cofactors in Mitochondrial Energy Production

Cofactors are compounds that assist with biological chemical reactions within the body. These can be vitamins, minerals, or coenzymes that work synergistically with enzymes in the production of ATP (our energy currency) by the mitochondria.


An essential mineral and is considered the second most common deficiency affecting about 70% of the American population. A lack of Magnesium increases blood pressure, reduces glucose tolerance, and causes abnormal neural excitations that impair sleep. 13 The best food sources of Magnesium are leafy greens, nuts, seeds, and cacao. Supplementing with Magnesium can have a calming effect on the body 14 and may improve sleep quality.

Better sleep means more energy throughout the day. Magnesium can be taken in pill form (as citrate, gluconate, or diglycinate) or rubbed on the body in the form of an oil. Alternatively, you can relax at the end of the day by soaking in a magnesium-rich Epsom salts bath. Magnesium L-threonate is considered a cognitive enhancer. 15 Avoid taking Magnesium, calcium, zinc, and iron at the same time as these minerals compete for absorption.

Coenzyme Q10

Naturally occurring in all cells of the body, although the heart, kidneys, and liver have the highest levels. CoQ10 plays a critical role in energy production and in protecting cells from oxidative damage. 16 As people with some diseases have reduced levels of this substance, including people who have fibromyalgia 17 18 19,have survived heart attacks or heart failure 20 21, have multiple sclerosis 22 23, are infertile 24 25 26, or suffer migraines. 27 28 Researchers have been interested in finding out whether CoQ10 supplements might have health benefits. CoQ10 enhances blood flow (through nitric oxide preservation), protects blood vessels, lowers oxidative stress, and boosts vitality in anyone who suffers from fatigue, but especially those people with the aforementioned conditions. Additionally, statin drugs are known to deplete CoQ10 levels 29, so supplementation is mandatory in people taking a statin. 30

Acetyl L-Carnitine (ALCAR)

Acetyl L-Carnitine (ALCAR) is a unique form of the amino acid L-Carnitine that is involved in energy production and mitochondrial biogenesis (the growth and creation of new mitochondria). It is known for boosting energy 31 32 33, improving alertness and cognitive function 34 35 and also improves insulin sensitivity 36, thus, indirectly increasing levels of Orexin. L-Carnitine has also been shown to effectively reduce depression 37, prevent neurological decline and chronic fatigue during aging 38 39 40 41 42 and improve cardiovascular health. 43

Incidentally, supplementing with ALCAR often results in fat loss because those taking it to tend to become more physically active due to the increased energy and vitality it yields.


A type of simple, five-carbon sugar that our bodies make. It is an essential component of adenosine triphosphate (ATP), which supplies energy to our cells. Normal, healthy tissue can make all the ribose it needs, but ATP production is hindered by inadequate ribose when we are stressed by overexertion. ATP production can drop by as much as 20% after a strenuous workout and may take up to 72 hours to fully recover. 44 45. Ribose supplementation may also help people who have suffered from heart disease or stroke. 46 47 48 Studies have also shown that D-ribose significantly reduced clinical symptoms in patients suffering from fibromyalgia and chronic fatigue syndrome. 49 Ribose cannot be found in food, so supplementing with it can have dramatic results, under the right conditions.


Creatine is among the most well-researched and effective supplements. Athletes, bodybuilders, and military personnel use dietary creatine as an ergogenic aid to boost physical performance in sports involving short bursts of high-intensity muscle activity. Creatine is thought to improve strength, increase lean muscle mass 50 51 52, and help the muscles recover more quickly during exercise. It has also been shown to have neuroprotective and cardioprotective benefits. 53 54 and increase cognitive function 55 56

Creatine is most effective when taken immediately after exercise with a meal containing carbohydrates.

Activators of Mitochondrial Biogenesis and Defense


(Phyllanthus Emblica) is also known as the Indian Gooseberry and is used in Ayurvedic medicine to treat many ailments. The health benefits of Amla berry can mostly be attributed to its high whole food vitamin C content and its impressive antioxidant abilities. Alma has been shown to have antiatherogenic, adaptogenic, cardioprotective, gastroprotective, antianemia, anti hypercholesterolemia, antidiarrheal, and neuroprotective properties. 57 It may also be useful in the prevention and treatment of cancer. 58


A sulfur-containing amino acid naturally found in animal proteins, including meat, seafood, dairy, and eggs. It is essential for cardiovascular function 59 and the development and function of skeletal muscle, the retina, and the brain. 60

Through signaling neurotransmitters in the brain, such as GABA and BDNF, it has anti-anxiety and antidepressant effects. It also affects Orexin by modulating and improving glucose sensitivity and glucose control. Eye, skin, endothelial, and kidney health can be improved by supplementing with taurine, especially in diabetics. Taurine is also essential for the proper function of mitochondria. 61 62

Alpha Lipoic Acid (ALA) – is a mitochondrial compound involved in energy metabolism. It is one of the most potent antioxidants produced naturally by the body but also found in a variety of foods and in supplement form. It reduces inflammation 63 64 and thereby directly improves energy levels. ALA can also reduce blood glucose levels when taken with a meal and thus maintain levels of the hormone Orexin, which promotes wakefulness.


Containing Curcumin, a yellow, bio-active compound known to possess powerful antioxidant and anti-inflammatory properties. It can help reduce depression and anxiety 65 66, slow cognitive decline with aging, promote cardiovascular health, reduce the risk of diabetes, and alleviate other inflammatory conditions, such as arthritis. Curcumin protects and stabilizes mitochondrial membranes and plays a role in mitochondrial biogenesis, thus improving energy levels.

To improve its bioavailability, Curcumin can be taken with piperine (found in high concentrations in black pepper), or as NovaSol®, CurcuWin® (136-fold), or LongVida®. – These are the most recommended forms.

Green Tea

Containing ECGC (epigallocatechin-3-gallate), a potent phytochemical with a host of health benefits ranging from cardioprotective 67 68, neuroprotective 69 70 and liver-protective to anti-diabetic 71, anti-obesogenic 72 73 74, anti-fatigue and even anti-carcinogenic effects! 75 76

ECGC works synergistically with L-Theanine to reduce anxiety and stress and is overall a very powerful protector of Mitochondria.

In a 12-week double-blind trial published in the American Journal of Clinical Nutrition, researchers gave 38 overweight adults, a daily polyphenol supplement, containing 282 milligrams of ECGC and 80 milligrams of Resveratrol (found in grape skins), or a placebo pill. People taking the polyphenol supplement had a highly significant increase in the function of mitochondria in their muscles compared to people given a placebo.


Pyrroloquinoline quinone is a redox agent (it reduces and oxidizes), which is capable of reducing oxidation by working synergistically with Glutathione.

It is found naturally in soil and foods such as kiwifruit, as well as in human breast milk. PQQ is known for preventing the development of damaging proteins associated with Parkinson’s disease and can stimulate the release of nerve growth factor cells in the brain. 77 It also supports mitochondrial function 78 and mitochondrial biogenesis. 79 80

NAD + regenerators

NAD + stands for nicotinamide adenine dinucleotide. It is a coenzyme found in all living cells. NAD is used to power metabolism by enabling the mitochondria to convert the food we eat into the energy our body needs to sustain all its functions. It also repairs damaged DNA, fortifies the cells’ defense systems, and sets the circadian rhythm.

However, the amount of NAD+ in your body naturally falls with age. 81 Lower levels of NAD+ are thought to impair biological functions important to health, which might contribute to age-related diseases. It’s believed that increasing NAD+ through supplementation may improve symptoms and/or delay these conditions.

The following supplements help maintain/boost levels of NAD:

Citrus Bioflavonoids

Phytonutrients found in citrus fruit. Hesperidin is the primary bioactive compound in orange peels, alongside naringenin. They are powerful antioxidant and anti-inflammatory molecules 82 83 capable of protecting against several degenerative diseases and particularly brain diseases. 84 These effects are mediated, in part, by their ability to prevent mitochondrial dysfunction and oxidative stress. 85

Flavonoids are also able to protect endothelial cells against a high glucose-induced decrease in NAD+ 86.


A polyphenol found in red wine that is associated with life extension and some of the health benefits of wine consumption. 87 It is produced in grape skins, peanuts, and some berries as a defense against toxins. It is a potent antioxidant that can protect against heart disease and insulin resistance 88, while also increasing blood flow (and oxygen and nutrient delivery) to the brain. 89

Moreover, unlike other antioxidants that interfere with exercise-induced adaptations 90, Resveratrol appears to enhance the physiological benefits of exercise. 91 92


A well-known bioflavonoid found in fruits and vegetables, particularly onions and apples. It is a potent antioxidant and anti-inflammatory molecule that is involved in mitochondrial energy production, the protection of mitochondria from oxidative stress 93 94 and mitochondrial biogenesis. It is also involved in helping the mitochondria regenerate NAD+, which is vital for energy production.

N-acetyl-Cysteine (NAC)

An immediate precursor to the most potent antioxidant that our body makes, glutathione. NAC also promotes detoxification and acts directly as a scavenger of free radicals. 95

Studies have shown that it can increase muscle performance and minimize muscle fatigue during exercise 96, as well as prevent the appearance of DNA damage, the decrease in mitochondrial respiration, and the loss of cellular levels of NAD+.97

Niacin and Nicotinamide

Two major forms of Vitamin B3 that are precursors of NAD+. They are known to boost NAD+ metabolism and stimulate the activity of certain enzymes that have been linked to numerous health benefits, including resistance to weight gain, improved control of blood sugar and cholesterol, reduced nerve damage, and a longer lifespan.

NAD+ is not bioavailable, meaning it can’t be taken orally and still survive the digestion process, therefore supplementing with its precursors, which do survive digestion, is necessary. 98 Of the various precursors of NAD+, Nicotinamide is one of the most efficient. 99

Reduce Stress with Adaptogens and Medicinal Mushrooms


Adaptogens are herbs that support the body’s ability to accommodate varying physical and emotional stresses. As stress can cause very real physical changes in the body, including harming the neurological, endocrine, and immune systems, supplementing with adaptogens can significantly improve mood and energy levels.

Research shows adaptogens can combat fatigue, enhance mental performance, and ease depression and anxiety. 100

Rhodiola Rosea

An adaptogen used in traditional Chinese medicine. Studies have shown that it very reliably reduces symptoms of fatigue and helps with depression, which is also commonly linked to fatigue. 101 102

By increasing dopamine signaling and thereby activating Orexin, it increases energy and wakefulness. In addition, studies have shown that it improves cognitive and physical performance and promotes longevity.


One of the most important adaptogenic herbs used in traditional Indian Ayurvedic medicine. It has been found to increase energy by increasing the body’s resilience to physical and mental stress. 103 It has also been shown to improve thyroid function 104 and improve physical performance in both sedentary people and athletes. Ashwagandha root extract is the preferred form of supplementation.

Panax Ginseng

A well-known Chinese traditional medicine that has gained recognition in the West during the last decade. It is popularly known to increase libido and appears to be effective for mood, immunity, and cognition. In addition, Panax Ginseng modulates and reduces blood glucose, which helps maintain levels of Orexin and thus promotes wakefulness. 105 Panax Ginseng has been shown to work synergistically with Gingko Biloba (another Chinese, antioxidant-rich herb used to enhance brain health and treat a variety of conditions).

Reishi Mushrooms

A rare mushroom that grows at the base of deciduous trees. It is known to have numerous health benefits, including boosting the immune system, relieving symptoms of chronic fatigue, and even treating cancer. 106

It is no surprise then that Reishi is known as the ancient “Mushroom of Immortality.” Regular, small-doses calms the body and may help regulate the body’s natural circadian rhythm. Reishi is also used in herbal medicine as an adaptogen, helping your body adapt to stress and improve energy levels.


A fungus that lives on certain caterpillars in the high mountain regions of China. Known as Himalayan Gold because it is often farmed in the Himalayan plateaus, Cordyceps has long been used in ancient Chinese and Tibetan medicine for curing diarrhea, headache, cough, rheumatism, liver disease, kidney disease, and much more. Clinical studies have shown improvements in the level of fatigue experienced by older adults supplementing with Cordyceps. 107

Cordyceps are thought to increase the body’s production of Adenosine Triphosphate (ATP), which is the primary energy carrier of the body. In another study, healthy elderly volunteers that were administered with Cordyceps while exercising on stationary bicycles showed significant increases in energy and oxygen-carrying capacity (VO2 max). 108

If you are looking to feel less tired or have more energy, adding dried and powdered Cordyceps to your coffee will probably help. Being rich in amino acids and vitamins like B1, B2, B12, and K, Cordyceps is full of energy-boosting nutrients. 109

Again, please be cautious if you take anti-hypertensive or anti-coagulant medication and speak with your health care provider before supplementation.


This is by no means an exhaustive list of supplements that enhance energy. For more information read the article titled “The Top Science-Backed Supplements For Energy Enhancement.”

Supplements can definitely help you stay alert and energized throughout the day, but they are no substitute to a solid foundation of regular exercise,  quality sleep, and a phytonutrient-rich diet. Supplements are after all supplements, meaning they are supplementary to optimal nutrition and lifestyle habits. There really is no way to replace a nutritious diet as foods often contain an array of vitamins, minerals, and phytonutrients that work synergistically with one another.

Having said that, you can see that many of the vitamins and supplements listed above have myriad unique positive side effects, beyond increasing energy, and are worthy compliments to a healthy lifestyle. Talk to your healthcare provider to assess your unique situation before starting any supplement regime to help support your powerhouse: your mitochondria.

Our Breakthough Mitochondrial Support Formula — Energenesis

We also strongly recommend you grab yourself a bottle (or 5) of our brand new breakthrough energy/mitochondria supplement, Energenesis. It’s packed with real doses of almost all the ingredients mentioned in this article, and is simply the most powerful mitochondrial formula ever created.

You can read about it HERE.


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Medically Reviewed ByEvan Hirsch, M.D.

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